SCHEMBL6140398

SCHEMBL6140398

COc1cc2c(cc1S(=O)(=O)c1ccc(OCc3cccc(F)c3)cc1)CN(C(=O)O)CC2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.48
NPC1 O15118 1/20 0.48
REV1 Q9UBZ9 1/20 0.45
GPR183 P32249 1/20 0.44
MAPT P10636 3/20 0.44
HCRTR2 O43614 2/20 0.43
ALDH1A1 P00352 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
HCRTR1 O43613 1/20 0.43
NR4A2 P43354 1/20 0.43
ABCB1 P08183 1/20 0.43
ABCC1 P33527 1/20 0.43
ADAMTS4 O75173 1/20 0.43
MMP13 P45452 1/20 0.43
MEN1 O00255 1/20 0.42
MMP1 P03956 1/20 0.42
MMP2 P08253 1/20 0.42
MMP9 P14780 1/20 0.42
MMP14 P50281 1/20 0.42
ADAM17 P78536 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4887148 0.90 KMT2A (0.43) KMT2ANPC1REV1GPR183MAPT
SCHEMBL13901032 0.89 MAPT (0.44) KMT2ANPC1REV1GPR183MAPT
SCHEMBL4890133 0.84 KMT2A (0.57) KMT2ANPC1ALDH1A1ABCB1MEN1
SCHEMBL29097908 0.81 NR4A2 (0.53) NPC1SMN1; SMN2NR4A2MAOB
SCHEMBL3895504 0.81 MAOB (0.42) NR4A2ADAMTS4MMP13MMP1MMP2
Hydrochloric Acid SCHEMBL3903185 0.80 MAOB (0.42) NR4A2ADAMTS4MMP13MMP1MMP2
SCHEMBL5565059 0.77 NPC1 (0.56) NPC1SMN1; SMN2NR4A2MAOB
SCHEMBL3900360 0.76 ESR2 (0.47) KMT2AREV1MAPTALDH1A1SMN1; SMN2
SCHEMBL3905464 0.74 MAOB (0.47) MAPTNR4A2ADAMTS4MMP13MMP1
Hydrochloric Acid SCHEMBL3900182 0.73 MAOB (0.47) MAPTNR4A2ADAMTS4MMP13MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1511727-A2 AROMATIC SULFONES AND THEIR MEDICAL USE GLAXO GROUP LIMITED (GB) 2005-03-09 EP disclosed
WO-2003099786-A2 AROMATIC SULFONES AND THEIR MEDICAL USE GLAXO GROUP LIMITED (GB) 2003-12-04 WO disclosed