Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 15/20 | 0.56 |
| ▸ | CDC7 | O00311 | 14/20 | 0.56 |
| ▸ | DBF4 | Q9UBU7 | 14/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.56 |
| ▸ | CDK2 | P24941 | 13/20 | 0.56 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL612018 | 0.92 | ROCK1 (0.56) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL613701 | 0.83 | CDC7 (0.66) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL613656 | 0.82 | ROCK1 (0.62) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL612621 | 0.82 | CDC7 (0.62) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL612136 | 0.82 | ROCK1 (0.70) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL612014 | 0.81 | ROCK1 (0.61) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL614079 | 0.81 | ROCK1 (0.60) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL613680 | 0.81 | ROCK1 (0.60) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL613283 | 0.81 | ROCK1 (0.62) | ROCK1CDC7DBF4CCNE1CDK2 | |
| SCHEMBL613316 | 0.80 | ROCK1 (0.51) | ROCK1CDC7DBF4CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040981-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040981-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | CDC7, CDK7, DTYMK | ROCK1 2609/4885CDC7 1/4885DBF4 593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.