SCHEMBL6142017

SCHEMBL6142017

C=CCCc1ccc(C#Cc2ccc([C@H]3CC[C@H](CCC=C)CC3)cc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 4/20 0.37
CYP2C9 P11712 2/20 0.35
SPHK1 Q9NYA1 3/20 0.33
ESR1 P03372 2/20 0.33
CYP3A4 P08684 1/20 0.33
ALOX5 P09917 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
MEN1 O00255 1/20 0.32
MAPK1 P28482 1/20 0.32
KMT2A Q03164 1/20 0.32
ACACB O00763 4/20 0.31
FFAR1 O14842 2/20 0.31
MAOA P21397 1/20 0.30
MAOB P27338 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7861973 0.91 CYP2C9 (0.47) ESR2CYP2C9SPHK1ALDH1A1LMNA
SCHEMBL6142073 0.91 SPHK1 (0.39) ESR2CYP2C9SPHK1ALDH1A1LMNA
SCHEMBL6141825 0.90 SPHK1 (0.39) ESR2CYP2C9SPHK1ALDH1A1LMNA
SCHEMBL6142175 0.89 SPHK1 (0.46) CYP2C9SPHK1ALDH1A1LMNAMAPT
SCHEMBL6142241 0.88 CYP2C9 (0.37) ESR2CYP2C9SPHK1ESR1CYP3A4
SCHEMBL7861911 0.88 SPHK1 (0.45) CYP2C9SPHK1ALDH1A1LMNAMAPT
SCHEMBL6141688 0.88 SPHK1 (0.37) CYP2C9SPHK1ALDH1A1LMNAMAPT
SCHEMBL6142068 0.88 SPHK1 (0.51) CYP2C9SPHK1
SCHEMBL6142274 0.88 SPHK1 (0.37) CYP2C9SPHK1ALDH1A1LMNAMAPT
SCHEMBL6142088 0.86 SPHK1 (0.43) CYP2C9SPHK1ALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0930286-B1 LIQUID-CRYSTAL ALKENYLTOLAN DERIVATIVE, LIQUID-CRYSTAL COMPOSITION, AND LIQUID-CRYSTAL DISPLAY ELEMENT CHISSO CORP (JP) 2005-01-12 EP disclosed
US-6333080-B1 HIGH ANISOTROPY, HIGH ELASTIC CONSTANT RATIO, EXCELLENT COMPARABILITY WITH OTHER LIQUID-CRYSTAL COMPOUNDS, AND LOW VISCOSITY AND ARE CHEMICALLY AND PHYSICALLY STABLE CHISSO CORPORATION (JP) 2001-12-25 US disclosed
EP-0930286-A1 LIQUID-CRYSTAL ALKENYLTOLAN DERIVATIVE, LIQUID-CRYSTAL COMPOSITION, AND LIQUID-CRYSTAL DISPLAY ELEMENT CHISSO CORPORATION (JP) 1999-07-21 EP disclosed