SCHEMBL6142146

SCHEMBL6142146

C=CCCc1ccc(C#Cc2ccc(-c3ccc(C#Cc4ccc(C)cc4)cc3)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 8/20 0.49
CYP1A2 P05177 2/20 0.37
CYP2A6 P11509 1/20 0.37
TAAR1 Q96RJ0 1/20 0.37
ACACB O00763 2/20 0.37
GRM5 P41594 1/20 0.37
POLB P06746 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA9 Q16790 1/20 0.35
KCNH2 Q12809 1/20 0.35
TSHR P16473 1/20 0.35
HSD17B10 Q99714 1/20 0.35
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7858804 1.00 FFAR1 (0.49) FFAR1CYP1A2CYP2A6TAAR1ACACB
SCHEMBL7861928 0.95 FFAR1 (0.53) FFAR1CYP1A2CYP2A6TAAR1ACACB
SCHEMBL19864925 0.89 CYP1A2 (0.45) CYP1A2CYP2A6TAAR1NPSR1KCNH2
SCHEMBL6142124 0.87 TSHR (0.41) FFAR1ACACBTSHRHSD17B10NPC1
SCHEMBL7858870 0.87 TSHR (0.41) FFAR1ACACBTSHRHSD17B10NPC1
SCHEMBL7851984 0.87 FFAR1 (0.39) FFAR1CYP1A2CYP2A6TAAR1ACACB
SCHEMBL6142110 0.87 FFAR1 (0.39) FFAR1CYP1A2CYP2A6TAAR1ACACB
SCHEMBL29637029 0.86 FFAR1 (0.41) FFAR1CHRM2S1PR1FPR1FPR3
SCHEMBL9584863 0.85 CYP1A1 (0.48) FFAR1CYP1A2ACACBTSHRHSD17B10
SCHEMBL2132364 0.84 CYP1A2 (0.50) FFAR1CYP1A2CYP2A6TAAR1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0930286-B1 LIQUID-CRYSTAL ALKENYLTOLAN DERIVATIVE, LIQUID-CRYSTAL COMPOSITION, AND LIQUID-CRYSTAL DISPLAY ELEMENT CHISSO CORP (JP) 2005-01-12 EP disclosed
US-6333080-B1 HIGH ANISOTROPY, HIGH ELASTIC CONSTANT RATIO, EXCELLENT COMPARABILITY WITH OTHER LIQUID-CRYSTAL COMPOUNDS, AND LOW VISCOSITY AND ARE CHEMICALLY AND PHYSICALLY STABLE CHISSO CORPORATION (JP) 2001-12-25 US disclosed
EP-0930286-A1 LIQUID-CRYSTAL ALKENYLTOLAN DERIVATIVE, LIQUID-CRYSTAL COMPOSITION, AND LIQUID-CRYSTAL DISPLAY ELEMENT CHISSO CORPORATION (JP) 1999-07-21 EP disclosed