Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | CCR3 | P51677 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 4/20 | 0.33 |
| ▸ | HRH2 | P25021 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | DRD4 | P21917 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | DRD5 | P21918 | 2/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6146890 | 0.85 | CCR3 (0.37) | KCNH2CCR3HRH1HRH2HTR1A | |
| SCHEMBL6150676 | 0.85 | KCNA5 (0.44) | KCNH2HRH1HRH2DRD3MEN1 | |
| SCHEMBL2966842 | 0.81 | CCR3 (0.44) | KCNH2CCR3HRH1HRH2HTR1A | |
| SCHEMBL6148397 | 0.81 | KCNH2 (0.53) | KCNH2MEN1KMT2A | |
| SCHEMBL2967583 | 0.77 | KCNH2 (0.45) | KCNH2CCR3HRH1HRH2DRD2 | |
| SCHEMBL2954294 | 0.75 | HRH1 (0.45) | KCNH2CCR3HRH1HRH2HTR1A | |
| SCHEMBL6093908 | 0.75 | CCR3 (0.46) | CCR3HRH1HRH2HTR1ADRD4 | |
| SCHEMBL2966214 | 0.74 | KCNH2 (0.44) | KCNH2CCR3HRH1HRH2DRD2 | |
| SCHEMBL6989013 | 0.73 | EPHX2 (0.45) | CCR3HRH1HRH2HTR1ADRD4 | |
| SCHEMBL2967483 | 0.73 | KCNH2 (0.48) | KCNH2CCR3HRH1HRH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235831-B1 | NEW OXABISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-03-30 | — | — | EP | claimed |