Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.32 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2964357 | 0.89 | POLB (0.39) | KCNH2SLC6A4HRH3DRD3MCHR1 | |
| SCHEMBL2966856 | 0.85 | SLC6A4 (0.40) | KCNH2SLC6A4HRH3DRD3MCHR1 | |
| SCHEMBL2966873 | 0.84 | KCNH2 (0.39) | KCNH2SLC6A4HRH3DRD3MCHR1 | |
| SCHEMBL2968077 | 0.84 | HRH3 (0.42) | KCNH2SLC6A4HRH3DRD3MCHR1 | |
| SCHEMBL2964346 | 0.82 | MCHR1 (0.43) | KCNH2SLC6A4HRH3MCHR1TMEM97 | |
| SCHEMBL6095424 | 0.82 | POLB (0.41) | SLC6A4HRH3DRD3MCHR1HIF1A | |
| SCHEMBL2959501 | 0.81 | KCNH2 (0.38) | KCNH2SLC6A4HRH3DRD3MCHR1 | |
| SCHEMBL4414313 | 0.81 | PDE4B (0.39) | KCNH2SLC6A4HRH3MAPT | |
| SCHEMBL5965486 | 0.81 | MCHR1 (0.40) | SLC6A4HRH3DRD3MCHR1KEAP1 | |
| SCHEMBL6739004 | 0.81 | POLB (0.40) | SLC6A4HRH3DRD3MCHR1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235831-B1 | NEW OXABISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-03-30 | — | — | EP | claimed |