Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | P4HB | P07237 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63771 | 0.90 | CXCR4 (0.38) | MEN1KMT2AP4HBCXCR4ALDH1A1 | |
| SCHEMBL62217 | 0.88 | MEN1 (0.40) | MEN1KMT2AP4HBCXCR4ALDH1A1 | |
| SCHEMBL63372 | 0.88 | CXCR4 (0.42) | MEN1KMT2AP4HBCXCR4ALDH1A1 | |
| SCHEMBL63341 | 0.88 | CXCR4 (0.44) | MEN1KMT2AP4HBCXCR4KCNH2 | |
| SCHEMBL62216 | 0.88 | MEN1 (0.40) | MEN1KMT2AP4HBCXCR4ALDH1A1 | |
| SCHEMBL62204 | 0.88 | MEN1 (0.40) | MEN1KMT2AP4HBCXCR4ALDH1A1 | |
| SCHEMBL62583 | 0.87 | MEN1 (0.43) | MEN1KMT2AP4HBCXCR4ALDH1A1 | |
| SCHEMBL72863 | 0.87 | MEN1 (0.42) | MEN1KMT2AP4HBCXCR4ALDH1A1 | |
| SCHEMBL62909 | 0.87 | MEN1 (0.42) | MEN1KMT2AP4HBCXCR4ALDH1A1 | |
| SCHEMBL61753 | 0.87 | MEN1 (0.40) | MEN1KMT2AP4HBCXCR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129395-B2 | 4,5-disubstituted-2-aryl pyrimidines | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-03-06 | — | — | US | disclosed |