Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 20/20 | 1.00 |
| ▸ | EDNRA | P25101 | 20/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.80 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.80 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.80 |
| ▸ | PDE4A | P27815 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sitaxentan SCHEMBL29372653 | 0.89 | EDNRA (1.00) | EDNRBEDNRAABCC3ABCC4ABCB11 | |
| SCHEMBL4631924 | 0.89 | EDNRA (0.87) | EDNRBEDNRAABCC3ABCC4ABCB11 | |
| Sitaxentan SCHEMBL803344 | 0.89 | EDNRA (1.00) | EDNRBEDNRAABCC3ABCC4ABCB11 | |
| SCHEMBL27467134 | 0.89 | EDNRA (0.80) | EDNRBEDNRAABCC3ABCC4ABCB11 | |
| SCHEMBL4631438 | 0.88 | EDNRA (0.79) | EDNRBEDNRAABCC3ABCC4ABCB11 | |
| Sitaxentan SCHEMBL4142779 | 0.88 | EDNRA (0.98) | EDNRBEDNRAABCC3ABCC4ABCB11 | |
| SCHEMBL4632107 | 0.88 | EDNRA (0.84) | EDNRBEDNRAABCC3ABCC4ABCB11 | |
| SCHEMBL27483184 | 0.88 | EDNRA (0.78) | EDNRBEDNRAABCC3ABCC4ABCB11 | |
| SCHEMBL4632337 | 0.87 | EDNRA (0.83) | EDNRBEDNRAABCC3ABCC4ABCB11 | |
| SCHEMBL4631478 | 0.86 | EDNRB (0.81) | EDNRBEDNRAABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980369-B1 | SULFONAMIDES FOR TREATMENT OF ENDOTHELIN-MEDIATED DISORDERS | ENCYSIVE PHARMACEUTICALS INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1498419-A1 | Process for preparing alkali metal salts of hydrophobic sulfonamides | ENCYSIVE PHARMACEUTICALS INC. (US) | 2005-01-19 | — | — | EP | disclosed |
| EP-0946552-B1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | ENCYSIVE PHARMACEUTICALS INC (US) | 2004-07-07 | — | — | EP | disclosed |