Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 20/20 | 0.81 |
| ▸ | EDNRB | P24530 | 18/20 | 0.81 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.68 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | PDE4A | P27815 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6151116 | 0.90 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL4631823 | 0.88 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL4631821 | 0.87 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL4630685 | 0.86 | EDNRA (0.80) | EDNRAEDNRB | |
| SCHEMBL4631376 | 0.86 | EDNRA (0.84) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL8584211 | 0.85 | EDNRA (0.88) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL4632379 | 0.85 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL4631420 | 0.84 | EDNRA (0.83) | EDNRAEDNRB | |
| SCHEMBL4630710 | 0.84 | EDNRA (0.85) | EDNRAEDNRB | |
| SCHEMBL4631355 | 0.84 | EDNRA (1.00) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819125-B1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORP (US) | 2003-06-18 | — | — | EP | claimed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | claimed |
| EP-0980369-B1 | SULFONAMIDES FOR TREATMENT OF ENDOTHELIN-MEDIATED DISORDERS | ENCYSIVE PHARMACEUTICALS INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1498419-A1 | Process for preparing alkali metal salts of hydrophobic sulfonamides | ENCYSIVE PHARMACEUTICALS INC. (US) | 2005-01-19 | — | — | EP | disclosed |
| EP-0946552-B1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | ENCYSIVE PHARMACEUTICALS INC (US) | 2004-07-07 | — | — | EP | disclosed |