Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.36 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 4/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6151265 | 1.00 | FOLH1 (0.37) | FOLH1KMT2AMEN1POLBTPSAB1 | |
| SCHEMBL6151257 | 1.00 | FOLH1 (0.37) | FOLH1KMT2AMEN1POLBTPSAB1 | |
| SCHEMBL6977783 | 0.82 | KMT2A (0.43) | FOLH1KMT2AMEN1POLBTPSAB1 | |
| SCHEMBL6977780 | 0.82 | KMT2A (0.43) | FOLH1KMT2AMEN1POLBTPSAB1 | |
| SCHEMBL6977776 | 0.82 | KMT2A (0.43) | FOLH1KMT2AMEN1POLBTPSAB1 | |
| SCHEMBL5887457 | 0.79 | ELANE (0.49) | FOLH1KMT2AMEN1POLBTPSAB1 | |
| SCHEMBL5887453 | 0.79 | ELANE (0.49) | FOLH1KMT2AMEN1POLBTPSAB1 | |
| SCHEMBL4366611 | 0.79 | ELANE (0.49) | FOLH1KMT2AMEN1POLBTPSAB1 | |
| SCHEMBL6984124 | 0.79 | FOLH1 (0.39) | FOLH1KMT2AMEN1POLBTPSAB1 | |
| SCHEMBL6984120 | 0.79 | FOLH1 (0.39) | FOLH1KMT2AMEN1POLBTPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1260222-B1 | Pharmaceutical compositions containing new iso-butenyl substituted taxanes | UNIV FLORIDA STATE (US) | 2005-10-26 | — | — | EP | disclosed |
| US-6872842-B2 | Antileukemia and antitumor agents | FLORIDA STATE UNIVERSITY (US) | 2005-03-29 | — | — | US | disclosed |
| EP-0668762-B1 | ISOBUTENYL-SUBSTITUTED TAXANES AND THEIR PHARMACEUTICAL COMPOSITIONS | UNIV FLORIDA STATE (US) | 2003-09-17 | — | — | EP | disclosed |
| US-20030045531-A1 | Antileukemia and antitumor agents | FLORIDA STATE UNIVERSITY | 2003-03-06 | — | — | US | disclosed |
| EP-1260222-A1 | Butenyl-substituted taxanes and composition | Florida State University (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6395895-B1 | Butenyl substituted β-lactams | FLORIDA STATE UNIVERSITY | 2002-05-28 | — | — | US | disclosed |
| US-6005138-A | ANTILEUKEMIA AND ANTITUMOR AGENTS | FLORIDA STATE UNIVERSITY (US) | 1999-12-21 | — | — | US | disclosed |
| US-5728850-A | ANTITUMOR AGENTS | FLORIDA STATE UNIVERSITY (US) | 1998-03-17 | — | — | US | disclosed |
| EP-0668762-A4 | BUTENYL-SUBSTITUTED TAXANES AND COMPOSITION. | UNIV FLORIDA STATE (US) | 1995-12-20 | — | — | EP | disclosed |
| EP-0668762-A1 | BUTENYL-SUBSTITUTED TAXANES AND COMPOSITION | FLORIDA STATE UNIVERSITY (US) | 1995-08-30 | — | — | EP | disclosed |
| WO-1994010996-A1 | BUTENYL-SUBSTITUTED TAXANES AND COMPOSITION | FLORIDA STATE UNIVERSITY (US) | 1994-05-26 | — | — | WO | disclosed |
| US-5284864-A | Antitumor and antileukemia agents | FLORIDA STATE UNIVERSITY (US) | 1994-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045531-A1 | Antileukemia and antitumor agents | MCL1, BCL3, BCL2L13 | FOLH1 1554/4885KMT2A 864/4885MEN1 1711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.