Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 20/20 | 0.48 |
| ▸ | EDNRB | P24530 | 16/20 | 0.48 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4665085 | 0.85 | EDNRA (0.58) | EDNRAEDNRB | |
| SCHEMBL4630638 | 0.83 | EDNRA (0.54) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL6150865 | 0.83 | EDNRA (0.54) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL6152466 | 0.75 | EDNRA (0.48) | EDNRAEDNRB | |
| SCHEMBL7212878 | 0.74 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL7014658 | 0.74 | EDNRA (0.55) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL6151651 | 0.73 | EDNRA (0.52) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL4630675 | 0.73 | EDNRB (0.58) | EDNRAEDNRB | |
| SCHEMBL7015862 | 0.73 | EDNRA (0.54) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL6152888 | 0.72 | EDNRA (0.48) | EDNRAEDNRBABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980369-B1 | SULFONAMIDES FOR TREATMENT OF ENDOTHELIN-MEDIATED DISORDERS | ENCYSIVE PHARMACEUTICALS INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1498419-A1 | Process for preparing alkali metal salts of hydrophobic sulfonamides | ENCYSIVE PHARMACEUTICALS INC. (US) | 2005-01-19 | — | — | EP | disclosed |
| EP-1498418-A1 | Sulfonamides for treatment of endothelin-mediated disorders | ENCYSIVE PHARMACEUTICALS INC. (US) | 2005-01-19 | — | — | EP | disclosed |
| EP-0946552-B1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | ENCYSIVE PHARMACEUTICALS INC (US) | 2004-07-07 | — | — | EP | disclosed |