Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 14/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152077 | 0.86 | F10 (0.63) | F10ATMMAPTSMN1; SMN2THRB | |
| SCHEMBL6305027 | 0.85 | F10 (0.66) | F10ATMMAPTSMN1; SMN2 | |
| SCHEMBL6306689 | 0.83 | F10 (0.63) | F10ATMMAPTSMN1; SMN2THRB | |
| SCHEMBL6152664 | 0.82 | F10 (0.65) | F10ATMMAPTTHRB | |
| SCHEMBL5733762 | 0.82 | F10 (0.72) | F10ATMSMN1; SMN2 | |
| SCHEMBL6306256 | 0.82 | F10 (0.67) | F10ATMSMN1; SMN2 | |
| SCHEMBL6299380 | 0.81 | F10 (0.66) | F10ATMMAPTSMN1; SMN2 | |
| SCHEMBL6386353 | 0.81 | F10 (0.66) | F10ATMMAPTSMN1; SMN2THRB | |
| SCHEMBL6152253 | 0.80 | F10 (0.65) | F10ATMMAPTTHRB | |
| SCHEMBL6300113 | 0.80 | F10 (0.65) | F10ATMMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082303-B1 | HETEROCYCLIC DERIVATIVES WHICH INHIBIT FACTOR XA | ASTRAZENECA AB (SE) | 2005-01-26 | — | — | EP | disclosed |
| US-6395731-B1 | ANTICOAGULANTS | ASTRAZENECA AB (SE) | 2002-05-28 | — | — | US | disclosed |
| EP-1082303-A1 | HETEROCYCLIC DERIVATIVES WHICH INHIBIT FACTOR XA | AstraZeneca AB (SE) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999057099-A1 | HETEROCYCLIC DERIVATIVES WHICH INHIBIT FACTOR XA | ASTRAZENECA AB (SE) | 1999-11-11 | — | — | WO | disclosed |