Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5987404 | 1.00 | CHRNA7 (0.51) | CHRNA7CHRM2CHRM1CHRM3 | |
| SCHEMBL6152342 | 1.00 | CHRNA7 (0.51) | CHRNA7CHRM2CHRM1CHRM3 | |
| SCHEMBL5987401 | 1.00 | CHRNA7 (0.51) | CHRNA7CHRM2CHRM1CHRM3 | |
| SCHEMBL6153257 | 0.85 | CHRNA7 (0.51) | CHRNA7CHRM2CHRM1CHRM3 | |
| SCHEMBL6152388 | 0.85 | NPC1 (0.58) | CHRNA7CHRM2CHRM1CHRM3 | |
| SCHEMBL5987676 | 0.85 | CHRNA7 (0.51) | CHRNA7CHRM2CHRM1CHRM3 | |
| SCHEMBL6153018 | 0.85 | CHRNA7 (0.51) | CHRNA7CHRM2CHRM1CHRM3 | |
| SCHEMBL6152740 | 0.85 | CHRNA7 (0.51) | CHRNA7CHRM2CHRM1CHRM3 | |
| SCHEMBL5986977 | 0.85 | CHRNA7 (0.52) | CHRNA7CHRM2CHRM1CHRM3 | |
| SCHEMBL5988428 | 0.85 | NPC1 (0.58) | CHRNA7CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233964-B1 | NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | claimed |
| EP-1233964-B1 | NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | disclosed |
| US-6683090-B1 | N-(1-AZABICYCLO(2.2.2)OCT-3-YL)PROPENAMIDE DERIVATIVES; PSYCHOTIC AND INTELLECTUAL IMPAIRMENT DISORDERS | ASTRAZENECA AB (SE) | 2004-01-27 | — | — | US | disclosed |