Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 7/20 | 0.82 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.69 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.69 |
| ▸ | CDK2 | P24941 | 5/20 | 0.67 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.67 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.63 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.61 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28771322 | 0.91 | CDK1 (0.79) | CDK1CDK5CDK5R1CDK2CCNE1 | |
| SCHEMBL31072401 | 0.91 | CDK1 (0.79) | CDK1CDK5CDK5R1CDK2CCNE1 | |
| SCHEMBL28459824 | 0.91 | CDK1 (0.79) | CDK1CDK5CDK5R1CDK2CCNE1 | |
| SCHEMBL1400442 | 0.90 | CDK1 (1.00) | CDK1CDK5CDK2CCNE1TDP1 | |
| SCHEMBL1443236 | 0.89 | TDP1 (0.80) | CDK1CDK5CDK5R1CDK2CCNE1 | |
| SCHEMBL17628615 | 0.89 | CDK1 (0.87) | CDK1CDK5CDK2CCNE1CCNE2 | |
| SCHEMBL27581376 | 0.88 | CDK5 (0.66) | CDK1CDK5CDK5R1CDK2CCNE1 | |
| SCHEMBL28461058 | 0.88 | CDK1 (0.78) | CDK1CDK5CDK5R1CDK2CCNE1 | |
| SCHEMBL1443449 | 0.87 | CDK1 (0.73) | CDK1CDK5CDK5R1CDK2CCNE1 | |
| SCHEMBL6821050 | 0.86 | CDK1 (0.79) | CDK1CDK5CDK2TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150982-B1 | PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND IkB-alpha | CV THERAPEUTICS INC (US) | 2005-10-12 | — | — | EP | disclosed |