SCHEMBL6152859

SCHEMBL6152859

O=C(C=Cc1ccncc1)N[C@H]1CN2CCC1CC2

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 5/20 0.47
CHRM2 P08172 4/20 0.47
CHRM1 P11229 4/20 0.47
CHRNA7 P36544 4/20 0.47
HTR3A P46098 2/20 0.46
HTR3E A5X5Y0 1/20 0.46
HTR3B O95264 1/20 0.46
ALOX15 P16050 1/20 0.46
TSHR P16473 1/20 0.46
HTR3D Q70Z44 1/20 0.46
HTR3C Q8WXA8 1/20 0.46
HPGD P15428 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
JUN P05412 1/20 0.43
NFKB1 P19838 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5988372 1.00 CHRM3 (0.47) CHRM3CHRM2CHRM1CHRNA7HTR3A
SCHEMBL5988374 1.00 CHRM3 (0.47) CHRM3CHRM2CHRM1CHRNA7HTR3A
SCHEMBL6152857 1.00 CHRM3 (0.47) CHRM3CHRM2CHRM1CHRNA7HTR3A
SCHEMBL374846 0.87 CHRNA7 (0.59) CHRM3CHRM2CHRM1CHRNA7HTR3A
SCHEMBL374845 0.87 CHRNA7 (0.59) CHRM3CHRM2CHRM1CHRNA7HTR3A
SCHEMBL6153288 0.87 CHRNA7 (0.59) CHRM3CHRM2CHRM1CHRNA7HTR3A
SCHEMBL6152691 0.87 CHRNA7 (0.59) CHRM3CHRM2CHRM1CHRNA7HTR3A
SCHEMBL6153668 0.87 CHRNA7 (0.59) CHRM3CHRM2CHRM1CHRNA7HTR3A
SCHEMBL6153661 0.87 CHRNA7 (0.59) CHRM3CHRM2CHRM1CHRNA7HTR3A
SCHEMBL5987468 0.87 CHRNA7 (0.59) CHRM3CHRM2CHRM1CHRNA7HTR3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1233964-B1 NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES ASTRAZENECA AB (SE) 2005-06-22 EP claimed
US-6683090-B1 N-(1-AZABICYCLO(2.2.2)OCT-3-YL)PROPENAMIDE DERIVATIVES; PSYCHOTIC AND INTELLECTUAL IMPAIRMENT DISORDERS ASTRAZENECA AB (SE) 2004-01-27 US claimed
EP-1233964-B1 NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES ASTRAZENECA AB (SE) 2005-06-22 EP disclosed
US-6683090-B1 N-(1-AZABICYCLO(2.2.2)OCT-3-YL)PROPENAMIDE DERIVATIVES; PSYCHOTIC AND INTELLECTUAL IMPAIRMENT DISORDERS ASTRAZENECA AB (SE) 2004-01-27 US disclosed
EP-0581165-A2 Acrylamide derivatives as antirussive agent DOMPE' FARMACEUTICI S.p.A. (IT) 1994-02-02 EP disclosed