Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Succinimide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.34 |
| ▸ | ITGAV | P06756 | 2/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.33 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinimide SCHEMBL20786978 | 1.00 | CRBN (0.58) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinimide SCHEMBL29132313 | 0.92 | CRBN (0.55) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinimide SCHEMBL1313847 | 0.92 | CRBN (0.69) | CRBNDDB1NPC1MAPK13MAPK12 | |
| Succinimide SCHEMBL28348066 | 0.90 | CRBN (0.52) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinimide SCHEMBL29278585 | 0.90 | CRBN (0.52) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinimide SCHEMBL6036901 | 0.89 | CRBN (0.73) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinimide SCHEMBL434236 | 0.89 | CRBN (0.73) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinimide SCHEMBL6717091 | 0.89 | CRBN (0.73) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinic Acid SCHEMBL28918359 | 0.88 | CRBN (0.50) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinic Acid SCHEMBL27856042 | 0.88 | CRBN (0.50) | CRBNITGB3ITGB1ITGAVITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116948733-B | Refrigerator oil composition for hydrocarbon refrigerant and method for producing the same | 山东源根石油化工有限公司 | 2024-01-12 | — | — | CN | disclosed |
| CN-116948733-A | Refrigerator oil composition for hydrocarbon refrigerant and method for producing the same | 山东源根石油化工有限公司 | 2023-10-27 | — | — | CN | disclosed |
| EP-0893439-B1 | A process for forming a modified polypeptide comprising a polypeptide and a polyalkylene oxide | ENZON INC (US) | 2005-07-27 | — | — | EP | disclosed |
| EP-0893439-A1 | Polypeptides modified by carbonates of polyalkylene oxide polymers | NOVO NORDISK A/S (DK) | 1999-01-27 | — | — | EP | disclosed |
| EP-0470128-A4 | ACTIVE CARBONATES OF POLYALKYLENE OXIDES FOR MODIFICATION OF POLYPEPTIDES | — | 1992-09-16 | — | — | EP | disclosed |
| EP-0470128-A1 | ACTIVE CARBONATES OF POLYALKYLENE OXIDES FOR MODIFICATION OF POLYPEPTIDES | NOVO NORDISK A/S (DK) | 1992-02-12 | — | — | EP | disclosed |
| WO-1990013540-A1 | ACTIVE CARBONATES OF POLYALKYLENE OXIDES FOR MODIFICATION OF POLYPEPTIDES | ENZON, INC. (US) | 1990-11-15 | — | — | WO | disclosed |