Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.58 |
| ▸ | ABL1 | P00519 | 2/20 | 0.58 |
| ▸ | RAF1 | P04049 | 2/20 | 0.58 |
| ▸ | LYN | P07948 | 2/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.55 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.55 |
| ▸ | AKT1 | P31749 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | MOK | Q9UQ07 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4086571 | 0.92 | MAPK14 (0.59) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4091881 | 0.90 | MAPK14 (0.57) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4092587 | 0.86 | ABL1 (0.65) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4082008 | 0.86 | MAPK14 (0.61) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4092496 | 0.84 | MAPK14 (0.59) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4098061 | 0.84 | MAPK14 (0.59) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4092957 | 0.84 | MAPK14 (0.63) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4261859 | 0.84 | MAPK14 (0.65) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4092250 | 0.83 | MAPK14 (0.72) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4098846 | 0.83 | MAPK14 (0.64) | MAPK14ABL1RAF1LYNMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534282-A2 | PHARMACEUTICAL COMPOSITIONS OF ANTICHOLINERGICS AND P38 KINASE INHIBITORS IN THE TREATMENT OF RESPIRATORY DISEASES | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2005-06-01 | — | — | EP | disclosed |
| EP-1494645-A2 | METHOD OF TREATING MUCUS HYPERSECRETION | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2005-01-12 | — | — | EP | disclosed |
| WO-2004004725-A2 | PHARMACEUTICAL COMPOSITIONS OF ANTICHOLINERGICS AND P38 KINASE INHIBITORS IN THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-01-15 | — | — | WO | disclosed |
| WO-2003084503-A2 | P38 KINASE INHIBITORS FOR TREATING MUCUS HYPERSECRETION_ | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-10-16 | — | — | WO | disclosed |