Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.55 |
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | RAF1 | P04049 | 3/20 | 0.46 |
| ▸ | LYN | P07948 | 3/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.46 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | CIT | O14578 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087098 | 0.93 | MAPK14 (0.63) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4097130 | 0.83 | MAPK14 (0.60) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4093055 | 0.80 | MAPK14 (0.70) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4091692 | 0.79 | MAPK14 (0.84) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4082232 | 0.79 | MAPK14 (0.69) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4082291 | 0.78 | MAPK14 (0.87) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4092895 | 0.75 | MAPK14 (0.68) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL5618956 | 0.75 | MAPK14 (0.75) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4082071 | 0.75 | MAPK14 (0.72) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6807373 | 0.74 | MAPK14 (0.81) | MAPK14ABL1RAF1LYNMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534282-A2 | PHARMACEUTICAL COMPOSITIONS OF ANTICHOLINERGICS AND P38 KINASE INHIBITORS IN THE TREATMENT OF RESPIRATORY DISEASES | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004004725-A2 | PHARMACEUTICAL COMPOSITIONS OF ANTICHOLINERGICS AND P38 KINASE INHIBITORS IN THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-01-15 | — | — | WO | disclosed |