Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.48 |
| ▸ | HTR3B | O95264 | 3/20 | 0.48 |
| ▸ | HTR3A | P46098 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153100 | 1.00 | CHRNA7 (0.56) | CHRNA7CHRM2CHRM1CHRM3ADRA2A | |
| SCHEMBL5987553 | 1.00 | CHRNA7 (0.56) | CHRNA7CHRM2CHRM1CHRM3ADRA2A | |
| SCHEMBL5987548 | 1.00 | CHRNA7 (0.56) | CHRNA7CHRM2CHRM1CHRM3ADRA2A | |
| SCHEMBL5987731 | 0.85 | CHRNA7 (0.56) | CHRNA7CHRM2CHRM1CHRM3ADRA2A | |
| SCHEMBL6153270 | 0.85 | CHRNA7 (0.56) | CHRNA7CHRM2CHRM1CHRM3ADRA2A | |
| SCHEMBL6152549 | 0.85 | CHRNA7 (0.56) | CHRNA7CHRM2CHRM1CHRM3ADRA2A | |
| SCHEMBL6153344 | 0.85 | CHRNA7 (0.56) | CHRNA7CHRM2CHRM1CHRM3ADRA2A | |
| SCHEMBL6153268 | 0.85 | CHRNA7 (0.56) | CHRNA7CHRM2CHRM1CHRM3ADRA2A | |
| SCHEMBL6152547 | 0.85 | CHRNA7 (0.56) | CHRNA7CHRM2CHRM1CHRM3ADRA2A | |
| SCHEMBL5987416 | 0.84 | CHRNA7 (0.59) | CHRNA7CHRM2CHRM1CHRM3ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233964-B1 | NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | claimed |
| EP-1551832-A1 | 8-AZABICYCLO[3.2.1]OCTANE ETHER DERIVATIVES AND THEIR USE AS NEUROKININ RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2005-07-13 | — | — | EP | disclosed |
| EP-1233964-B1 | NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004031185-A1 | 8-AZABICYCLO[3.2.1]OCTANE ETHER DERIVATIVES AND THEIR USE AS NEUROKININ RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2004-04-15 | — | — | WO | disclosed |
| US-6683090-B1 | N-(1-AZABICYCLO(2.2.2)OCT-3-YL)PROPENAMIDE DERIVATIVES; PSYCHOTIC AND INTELLECTUAL IMPAIRMENT DISORDERS | ASTRAZENECA AB (SE) | 2004-01-27 | — | — | US | disclosed |
| EP-1233964-A1 | NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2002-08-28 | — | — | EP | disclosed |
| WO-2001036417-A1 | NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-05-25 | — | — | WO | disclosed |