Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29208593 | 0.67 | KDM4E (0.31) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL16179 | 0.63 | KDM4E (0.36) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL14812753 | 0.63 | KDM4E (0.33) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL40747 | 0.63 | KDM4E (0.33) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL14812750 | 0.63 | KDM4E (0.33) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL20526419 | 0.61 | KDM4E (0.35) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL448708 | 0.61 | KDM4E (0.35) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Dibenzo[B,F]Oxepine SCHEMBL1650179 | 0.60 | MEN1 (0.64) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL7853855 | 0.60 | — | — | |
| SCHEMBL11007003 | 0.60 | PARP1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1044190-B1 | SYNTHESIS OF 11-ARYL-5,6-DIHYDRO-11H-DIBENZ(B,E)AZEPINES | JOHNSON MATTHEY PHARMACEUTICAL (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5677298-A | USEFUL FOR THE PROPHYLAXIS OR THERAPY OF HYPERCHOLESTEREMIA OR CORONOARY SCLEROSIS OF MAMMALS | TAKEDA CHEMICAL INDUSTRIES (JP) | 1997-10-14 | — | — | US | disclosed |