Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.85 |
| ▸ | FER | P16591 | 7/20 | 0.85 |
| ▸ | JAK2 | O60674 | 2/20 | 0.71 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.71 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.71 |
| ▸ | HCK | P08631 | 2/20 | 0.71 |
| ▸ | ROS1 | P08922 | 2/20 | 0.71 |
| ▸ | PIM1 | P11309 | 2/20 | 0.71 |
| ▸ | PRKACA | P17612 | 2/20 | 0.71 |
| ▸ | MARK3 | P27448 | 2/20 | 0.71 |
| ▸ | LTK | P29376 | 2/20 | 0.71 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.71 |
| ▸ | CLK2 | P49760 | 2/20 | 0.71 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.71 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.71 |
| ▸ | MAP3K10 | Q02779 | 2/20 | 0.71 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.71 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.71 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.71 |
| ▸ | STK3 | Q13188 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154803 | 1.00 | SYK (0.85) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL2713511 | 0.92 | SYK (1.00) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL2713216 | 0.92 | SYK (1.00) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL18925786 | 0.91 | SYK (0.77) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL9233108 | 0.91 | SYK (0.77) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL5028128 | 0.86 | SYK (0.70) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL18925524 | 0.83 | SYK (0.69) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL22068320 | 0.83 | JAK2 (0.68) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL5027894 | 0.83 | SYK (0.66) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL9103494 | 0.83 | SYK (0.66) | SYKFERJAK2ROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1184376-B1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-02-02 | — | — | EP | claimed |
| EP-1184376-A1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-03-06 | — | — | EP | claimed |
| EP-1184376-B1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-02-02 | — | — | EP | disclosed |
| US-6797706-B1 | Heterocyclecarboxamide derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2004-09-28 | — | — | US | disclosed |
| EP-1184376-A1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-03-06 | — | — | EP | disclosed |