Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.69 |
| ▸ | FER | P16591 | 2/20 | 0.69 |
| ▸ | CDC7 | O00311 | 1/20 | 0.69 |
| ▸ | PLK4 | O00444 | 1/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.69 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.69 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.69 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.69 |
| ▸ | JAK2 | O60674 | 1/20 | 0.69 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.69 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.69 |
| ▸ | PAK4 | O96013 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.69 |
| ▸ | PRKCG | P05129 | 1/20 | 0.69 |
| ▸ | LCK | P06239 | 1/20 | 0.69 |
| ▸ | FYN | P06241 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6155612 | 1.00 | LRRK2 (0.69) | LRRK2MAPK1CHEK2FERCDC7 | |
| SCHEMBL14956519 | 0.88 | LRRK2 (0.71) | LRRK2MAPK1CHEK2FERCDC7 | |
| SCHEMBL14985321 | 0.88 | LRRK2 (0.66) | LRRK2MAPK1CHEK2FERCDC7 | |
| SCHEMBL14955690 | 0.85 | LCK (0.68) | LRRK2MAPK1CHEK2FERCDC7 | |
| SCHEMBL14955932 | 0.85 | LCK (0.68) | LRRK2MAPK1CHEK2FERCDC7 | |
| SCHEMBL14955619 | 0.83 | LRRK2 (0.67) | LRRK2MAPK1CHEK2FERCDC7 | |
| SCHEMBL14955364 | 0.83 | LRRK2 (0.65) | LRRK2MAPK1CHEK2FERCDC7 | |
| SCHEMBL14955324 | 0.83 | LRRK2 (0.67) | LRRK2MAPK1CHEK2FERCDC7 | |
| SCHEMBL14955998 | 0.83 | FER (0.72) | LRRK2MAPK1CHEK2FERCDC7 | |
| SCHEMBL14955556 | 0.83 | LRRK2 (0.67) | LRRK2MAPK1CHEK2FERCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1184376-B1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-02-02 | — | — | EP | claimed |
| US-6797706-B1 | Heterocyclecarboxamide derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2004-09-28 | — | — | US | claimed |
| EP-1184376-A1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-03-06 | — | — | EP | claimed |
| EP-1184376-B1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-02-02 | — | — | EP | disclosed |
| US-6797706-B1 | Heterocyclecarboxamide derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2004-09-28 | — | — | US | disclosed |
| EP-1184376-A1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-03-06 | — | — | EP | disclosed |