Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.69 |
| ▸ | CDC7 | O00311 | 1/20 | 0.69 |
| ▸ | PLK4 | O00444 | 1/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.69 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.69 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.69 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.69 |
| ▸ | JAK2 | O60674 | 1/20 | 0.69 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.69 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.69 |
| ▸ | PAK4 | O96013 | 1/20 | 0.69 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.69 |
| ▸ | PRKCG | P05129 | 1/20 | 0.69 |
| ▸ | FYN | P06241 | 1/20 | 0.69 |
| ▸ | CDK1 | P06493 | 1/20 | 0.69 |
| ▸ | CSF1R | P07333 | 1/20 | 0.69 |
| ▸ | RET | P07949 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14955780 | 1.00 | LCK (0.69) | LCKCDC7PLK4CHEK1PDPK1 | |
| SCHEMBL6156484 | 1.00 | LCK (0.69) | LCKCDC7PLK4CHEK1PDPK1 | |
| SCHEMBL14961922 | 1.00 | LCK (0.69) | LCKCDC7PLK4CHEK1PDPK1 | |
| SCHEMBL14955717 | 0.92 | LCK (0.66) | LCKCDC7PLK4CHEK1PDPK1 | |
| SCHEMBL6155019 | 0.91 | FER (0.78) | LCKCDC7PLK4CHEK1PDPK1 | |
| SCHEMBL6155014 | 0.91 | FER (0.78) | LCKCDC7PLK4CHEK1PDPK1 | |
| SCHEMBL14955851 | 0.89 | LRRK2 (0.67) | LCKCDC7PLK4CHEK1PDPK1 | |
| SCHEMBL14956239 | 0.87 | FER (0.67) | LCKCDC7PLK4CHEK1PDPK1 | |
| SCHEMBL14955998 | 0.87 | FER (0.72) | LCKCDC7PLK4CHEK1PDPK1 | |
| SCHEMBL14955556 | 0.87 | LRRK2 (0.67) | LCKCDC7PLK4CHEK1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1184376-B1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-02-02 | — | — | EP | claimed |
| US-6797706-B1 | Heterocyclecarboxamide derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2004-09-28 | — | — | US | claimed |
| EP-1184376-A1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-03-06 | — | — | EP | claimed |
| EP-1184376-B1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-02-02 | — | — | EP | disclosed |
| US-6797706-B1 | Heterocyclecarboxamide derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2004-09-28 | — | — | US | disclosed |
| EP-1184376-A1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-03-06 | — | — | EP | disclosed |