Acetic Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CALCR CHRNA3 CHRNB4 ESR1 ESR2 GHSR GNRHR GSC1 HSPA8 MALT1 MC1R MC4R NOS1 NOS2 NOS3 OPRK1 OXTR RAMP1 RAMP2 RAMP3 SCN5A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 dacA dacB dacC folP ftsI mrcA mrcB mrdA rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	FFAR3	O14843	3/20	0.47

▸	LCK	P06239	1/20	0.47

▸	FYN	P06241	1/20	0.47

▸	ALDH1A1	P00352	4/20	0.39

▸	TDP1	Q9NUW8	2/20	0.39

▸	LMNA	P02545	5/20	0.35

▸	ALOX15	P16050	2/20	0.35

▸	BLM	P54132	1/20	0.35

▸	PMP22	Q01453	1/20	0.35

▸	HDAC3	O15379	1/20	0.33

▸	HDAC1	Q13547	1/20	0.33

▸	HDAC2	Q92769	1/20	0.33

▸	HDAC8	Q9BY41	1/20	0.33

▸	TSHR	P16473	2/20	0.32

▸	CHRM2	P08172	1/20	0.32

▸	CHRM4	P08173	1/20	0.32

▸	CHRM5	P08912	1/20	0.32

▸	CHRM1	P11229	1/20	0.32

▸	CHRM3	P20309	1/20	0.32

▸	GLA	P06280	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Acetic Acid SCHEMBL21802739	0.84	FFAR3 (0.44)	FFAR3LCKFYNALDH1A1TDP1
Acetic Acid SCHEMBL5903251	0.78	FFAR3 (0.44)	FFAR3LCKFYNALDH1A1TDP1
Acetic Acid SCHEMBL29114515	0.78	FFAR3 (0.44)	FFAR3LCKFYNALDH1A1TDP1
Acetic Acid SCHEMBL22152	0.76	FFAR3 (0.50)	FFAR3LCKFYNALDH1A1TDP1
Acetic Acid SCHEMBL31218573	0.76	FFAR3 (0.50)	FFAR3LCKFYNALDH1A1TDP1
Acetic Acid SCHEMBL16244302	0.76	FFAR3 (0.50)	FFAR3LCKFYNALDH1A1TDP1
Acetic Acid SCHEMBL28664565	0.76	FFAR3 (0.50)	FFAR3LCKFYNALDH1A1TDP1
Acetic Acid SCHEMBL19356582	0.76	FFAR3 (0.50)	FFAR3LCKFYNALDH1A1TDP1
N,N-Dimethylethanaminium SCHEMBL3408050	0.76	—	—
Acetic Acid SCHEMBL28549045	0.76	FFAR3 (0.50)	FFAR3LCKFYNALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20050065118-A1	Organosulfur inhibitors of tyrosine phosphatases	METABASIS THERAPEUTICS, INC.	2005-03-24	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20050065118-A1	Organosulfur inhibitors of tyrosine phosphatases	PTPRS, PTPRJ, PTPRCAP	FFAR3 4261/4885LCK 43/4885FYN 83/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.