Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 8/20 | 0.59 |
| ▸ | AKT1 | P31749 | 11/20 | 0.55 |
| ▸ | AKT2 | P31751 | 1/20 | 0.50 |
| ▸ | AKT1S1 | Q96B36 | 1/20 | 0.50 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14537168 | 0.92 | MC4R (0.49) | MC4RAKT1AKT2AKT3LMNA | |
| SCHEMBL6156384 | 0.83 | DPP4 (0.45) | MC4RAKT1AKT2AKT1S1AKT3 | |
| SCHEMBL4682255 | 0.82 | AKT1 (0.62) | MC4RAKT1AKT2AKT1S1AKT3 | |
| SCHEMBL14537172 | 0.81 | MC4R (0.53) | MC4RLMNAGLATSHR | |
| SCHEMBL14458722 | 0.81 | KCNH2 (0.45) | MC4R | |
| SCHEMBL4515320 | 0.79 | MC4R (0.63) | MC4RAKT1AKT2AKT1S1AKT3 | |
| SCHEMBL5331894 | 0.79 | MC4R (0.58) | MC4RAKT1AKT2AKT1S1AKT3 | |
| SCHEMBL14355908 | 0.79 | MC4R (0.58) | MC4RAKT1AKT2AKT1S1AKT3 | |
| SCHEMBL5337821 | 0.78 | MC4R (0.64) | MC4RAKT1AKT2AKT1S1AKT3 | |
| SCHEMBL4509578 | 0.76 | AKT1 (0.62) | MC4RAKT1AKT2AKT1S1AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005054278-A1 | SUBSTITUTED N-BENZYL-LACTAM DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2005-06-16 | — | — | WO | disclosed |
| EP-1538159-A1 | Substituted N-benzyl-lactam derivatives as melanocortin-4 receptor agonists | Santhera Pharmaceuticals (Schweiz) GmbH (CH) | 2005-06-08 | — | — | EP | disclosed |