Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 12/20 | 0.56 |
| ▸ | TACR1 | P25103 | 6/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6159104 | 0.82 | TACR2 (0.55) | TACR2TACR1OPRL1OPRM1 | |
| SCHEMBL6160705 | 0.80 | CYP11B1 (0.45) | TACR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6160878 | 0.79 | TACR2 (0.56) | TACR2TACR1OPRL1OPRM1 | |
| Hydrochloric Acid SCHEMBL9317762 | 0.76 | TACR2 (0.65) | TACR2TACR1OPRL1OPRM1 | |
| SCHEMBL7870017 | 0.75 | TACR2 (0.61) | TACR2TACR1OPRL1OPRM1SLC6A2 | |
| SCHEMBL6952533 | 0.74 | TACR2 (0.61) | TACR2TACR1OPRL1OPRM1SLC6A2 | |
| Hydrochloric Acid SCHEMBL7871909 | 0.74 | TACR2 (0.61) | TACR2TACR1OPRL1OPRM1SLC6A2 | |
| Hydrochloric Acid SCHEMBL9319134 | 0.74 | TACR2 (0.63) | TACR2TACR1OPRL1 | |
| SCHEMBL7812116 | 0.73 | TACR2 (0.67) | TACR2TACR1 | |
| SCHEMBL6164928 | 0.73 | CYP11B1 (0.44) | TACR2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739891-B1 | Substituted heterocycles | ASTRAZENECA AB (SE) | 2005-01-19 | — | — | EP | disclosed |
| US-6355695-B1 | ANTIHISTAMINES; ASTHMA THERAPY | ZENECA LIMITED (SE) | 2002-03-12 | — | — | US | disclosed |
| US-6235757-B1 | ANTIHISTAMINES | ZENECA LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-6051580-A | Substituted heterocycles | ZENECA LIMITED | 2000-04-18 | — | — | US | disclosed |
| US-5889024-A | Substituted heterocycles | ZENECA LIMITED (GB) | 1999-03-30 | — | — | US | disclosed |
| EP-0739891-A2 | Substituted heterocycles | ZENECA LIMITED (GB) | 1996-10-30 | — | — | EP | disclosed |