Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 6/20 | 0.67 |
| ▸ | MMP12 | P39900 | 2/20 | 0.59 |
| ▸ | ACE | P12821 | 2/20 | 0.58 |
| ▸ | CPA1 | P15085 | 2/20 | 0.58 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160503 | 1.00 | MME (0.67) | MMEMMP12ACECPA1ACE2 | |
| SCHEMBL6161548 | 1.00 | MME (0.67) | MMEMMP12ACECPA1ACE2 | |
| SCHEMBL6159984 | 0.90 | MME (0.69) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL6159992 | 0.90 | MME (0.69) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL6162138 | 0.90 | MME (0.69) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL6171524 | 0.89 | MME (0.82) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL6168678 | 0.89 | MME (0.82) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL6161373 | 0.86 | MME (0.64) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL6161861 | 0.86 | MME (0.64) | MMEACECPA1ACE2HRH4 | |
| SCHEMBL6161376 | 0.86 | MME (0.64) | MMEACECPA1ACE2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | claimed |
| EP-0877740-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2005-03-30 | — | — | EP | disclosed |
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | disclosed |