Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.63 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.63 |
| ▸ | FER | P16591 | 4/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160178 | 1.00 | SYK (0.63) | SYKMAPK1MAPK3KCNH2AURKB | |
| SCHEMBL6155628 | 0.84 | SYK (0.61) | SYKMAPK1MAPK3KCNH2AURKB | |
| SCHEMBL6155632 | 0.84 | SYK (0.61) | SYKMAPK1MAPK3KCNH2AURKB | |
| SCHEMBL6155667 | 0.83 | SYK (0.70) | SYKMAPK1MAPK3KCNH2AURKB | |
| SCHEMBL6155657 | 0.83 | SYK (0.70) | SYKMAPK1MAPK3KCNH2AURKB | |
| SCHEMBL2720052 | 0.79 | SYK (0.62) | SYKMAPK1MAPK3KCNH2AURKB | |
| SCHEMBL8195233 | 0.78 | STAT6 (0.50) | SYKKCNH2AURKB | |
| SCHEMBL2386517 | 0.78 | SYK (1.00) | SYKMAPK1MAPK3KCNH2AURKB | |
| SCHEMBL2386521 | 0.78 | SYK (1.00) | SYKMAPK1MAPK3KCNH2AURKB | |
| SCHEMBL29357565 | 0.78 | SYK (1.00) | SYKMAPK1MAPK3KCNH2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1184376-B1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-02-02 | — | — | EP | disclosed |
| US-6797706-B1 | Heterocyclecarboxamide derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2004-09-28 | — | — | US | disclosed |
| EP-1184376-A1 | NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-03-06 | — | — | EP | disclosed |