Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.68 |
| ▸ | ACE | P12821 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8693644 | 0.94 | MME (0.58) | MMEACEHPGDHRH4 | |
| SCHEMBL6162600 | 0.93 | MME (0.66) | MMEACEHPGDHRH4 | |
| SCHEMBL8861658 | 0.88 | MME (0.62) | MMEACEHPGDHRH4 | |
| SCHEMBL8861642 | 0.87 | HPGD (0.51) | MMEACEHPGD | |
| SCHEMBL8861605 | 0.85 | HPGD (0.54) | MMEACEHPGD | |
| SCHEMBL8861700 | 0.85 | MME (0.65) | MMEACEHPGD | |
| SCHEMBL8861619 | 0.83 | HPGD (0.52) | MMEACEHPGD | |
| SCHEMBL8861638 | 0.82 | HPGD (0.52) | HPGD | |
| SCHEMBL8861655 | 0.82 | MME (0.62) | MMEACEHPGD | |
| SCHEMBL8861615 | 0.82 | MME (0.62) | MMEACEHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419327-B1 | Amino acid derivatives, method for their preparation and their therapeutic application | BIOPROJET SOC CIV (FR) | 1994-07-27 | — | — | EP | claimed |
| EP-0877740-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2005-03-30 | — | — | EP | disclosed |
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | disclosed |
| US-5599951-A | ENZYME INHIBITORS | SOCIETE CIVILE BIOPROJET (FR) | 1997-02-04 | — | — | US | disclosed |