Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 16/20 | 0.85 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.61 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.57 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.57 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160984 | 1.00 | DPP4 (0.85) | DPP4HDAC8DPP7DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL6162984 | 0.99 | DPP4 (0.83) | DPP4HDAC8DPP7DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL6162992 | 0.99 | DPP4 (0.83) | DPP4HDAC8DPP7DPP8DPP9 | |
| SCHEMBL3137617 | 0.91 | DPP4 (0.71) | DPP4HDAC8 | |
| SCHEMBL27851935 | 0.91 | DPP4 (0.71) | DPP4HDAC8 | |
| Hydrochloric Acid SCHEMBL6163310 | 0.90 | DPP4 (0.70) | DPP4HDAC8 | |
| Hydrochloric Acid SCHEMBL6163320 | 0.90 | DPP4 (0.70) | DPP4HDAC8 | |
| SCHEMBL14305531 | 0.86 | DPP4 (0.72) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL13852680 | 0.85 | DPP4 (0.64) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL6161265 | 0.84 | DPP4 (0.67) | DPP4HDAC8DPP7DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0832065-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |