Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.77 |
| ▸ | HTR6 | P50406 | 3/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
| ▸ | GSK3B | P49841 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.48 |
| ▸ | NFATC1 | O95644 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22214644 | 0.88 | DYRK1A (0.62) | DYRK1AHTR6KCNH2GSK3BKDM4E | |
| SCHEMBL1883807 | 0.88 | KDM4E (0.58) | DYRK1AHTR6KCNH2GSK3BKDM4E | |
| SCHEMBL13335069 | 0.86 | KDM4E (0.57) | DYRK1AHTR6KCNH2GSK3BKDM4E | |
| SCHEMBL9265311 | 0.84 | DYRK1A (0.57) | DYRK1AHTR6KCNH2GSK3BKDM4E | |
| SCHEMBL12091869 | 0.84 | DYRK1A (0.56) | DYRK1AHTR6KCNH2GSK3BKDM4E | |
| SCHEMBL22214642 | 0.84 | DYRK1A (0.56) | DYRK1AHTR6KCNH2GSK3BKDM4E | |
| SCHEMBL22214768 | 0.83 | DYRK1A (0.56) | DYRK1AHTR6KCNH2GSK3BKDM4E | |
| SCHEMBL13335089 | 0.82 | KDM4E (0.57) | DYRK1AHTR6KCNH2GSK3BKDM4E | |
| SCHEMBL12177017 | 0.82 | KDM4E (0.64) | DYRK1AKCNH2GSK3BKDM4EPOLB | |
| SCHEMBL22214767 | 0.81 | DYRK1A (0.53) | DYRK1AHTR6KCNH2GSK3BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |