Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 3/20 | 0.49 |
| ▸ | HRH1 | P35367 | 3/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | VNN1 | O95497 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7556302 | 0.90 | KMT2A (0.62) | KMT2ACYP51A1MAPK1PABPC1HRH2 | |
| SCHEMBL7556296 | 0.90 | KMT2A (0.62) | KMT2ACYP51A1MAPK1PABPC1HRH2 | |
| SCHEMBL5891895 | 0.90 | KMT2A (0.54) | KMT2ACYP51A1MAPK1PABPC1HRH2 | |
| SCHEMBL6162484 | 0.88 | KMT2A (0.71) | KMT2ACYP51A1MAPK1PABPC1HRH2 | |
| SCHEMBL6162477 | 0.88 | KMT2A (0.71) | KMT2ACYP51A1MAPK1PABPC1HRH2 | |
| SCHEMBL6162815 | 0.88 | KMT2A (0.71) | KMT2ACYP51A1MAPK1PABPC1HRH2 | |
| SCHEMBL7598387 | 0.83 | CHRM1 (0.52) | KMT2AMAPK1PABPC1HRH2HRH1 | |
| SCHEMBL6163231 | 0.83 | KMT2A (0.59) | KMT2ACYP51A1MAPK1PABPC1HRH2 | |
| SCHEMBL6163240 | 0.83 | KMT2A (0.59) | KMT2ACYP51A1MAPK1PABPC1HRH2 | |
| SCHEMBL6162295 | 0.82 | KMT2A (0.58) | KMT2ACYP51A1MAPK1PABPC1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0832065-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |