Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | CCR1 | P32246 | 3/20 | 0.50 |
| ▸ | CCR5 | P51681 | 3/20 | 0.50 |
| ▸ | CCR8 | P51685 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3463942 | 0.98 | GRM5 (0.55) | GRM5KDM4ELMNACCR1CCR5 | |
| SCHEMBL9383460 | 0.82 | GRM5 (0.65) | GRM5KDM4ELMNAPOLBTP53 | |
| SCHEMBL5215431 | 0.81 | GRM5 (0.45) | GRM5KDM4ELMNACCR1CCR5 | |
| SCHEMBL30795324 | 0.80 | GRM5 (0.64) | GRM5KDM4ELMNACCR1CCR5 | |
| SCHEMBL3923785 | 0.80 | GRM5 (0.64) | GRM5KDM4ELMNACCR1CCR5 | |
| SCHEMBL6449004 | 0.78 | GRM5 (0.50) | GRM5KDM4ELMNANPC1RAB9A | |
| SCHEMBL3928998 | 0.78 | GRM5 (0.68) | GRM5KDM4EHTTALDH1A1MAPT | |
| SCHEMBL3923978 | 0.78 | HTT (0.44) | GRM5KDM4ELMNACCR1CCR5 | |
| SCHEMBL3923546 | 0.76 | GRM5 (0.49) | GRM5KDM4ELMNACCR1CCR5 | |
| SCHEMBL25436071 | 0.76 | GRM5 (0.58) | GRM5CYP1A2TP53SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0770610-B1 | Biospecific binding reactants labelled with luminescent lanthanide chelates and their use | WALLAC OY (FI) | 2005-07-06 | — | — | EP | disclosed |
| US-5859215-A | IMMUNOASSAY; DNA HYBRID ANALYSIS; COMPLEXING; MEDICAL DIAGNOSIS | WALLAC OY (FI) | 1999-01-12 | — | — | US | disclosed |
| EP-0770610-A1 | Biospecific binding reactants labelled with luminescent lanthanide chelates and their use | WALLAC OY (FI) | 1997-05-02 | — | — | EP | disclosed |