Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL795038 | 0.89 | EDNRA (0.46) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL6161456 | 0.86 | EDNRA (0.38) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL14097336 | 0.79 | EDNRA (0.38) | EDNRASMN1; SMN2SLC22A12ALOX5APALOX5 | |
| SCHEMBL7502687 | 0.79 | EDNRA (0.42) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8415160 | 0.77 | EDNRA (0.46) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8434773 | 0.77 | EDNRA (0.47) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL6577534 | 0.76 | EDNRA (0.36) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8785538 | 0.76 | SLC22A12 (0.45) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8435187 | 0.75 | EDNRA (0.44) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8415300 | 0.75 | MAPT (0.37) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863896-B1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | AVENTIS PHARMA SA (FR) | 2005-02-09 | — | — | EP | disclosed |
| US-5986103-A | IMIDAZOLE SUBSTITUTED BENZENE AND REDUCTION OF ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-11-16 | — | — | US | disclosed |
| EP-0863896-A1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | HOECHST MARION ROUSSEL (FR) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997017340-A1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | HOECHST MARION ROUSSEL (FR) | 1997-05-15 | — | — | WO | disclosed |