Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 7/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172696 | 0.93 | TACR2 (0.41) | TACR2MCHR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6172692 | 0.93 | TACR2 (0.41) | TACR2MCHR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7045680 | 0.82 | TACR2 (0.47) | TACR2MCHR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5866364 | 0.82 | TACR2 (0.47) | TACR2MCHR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6665274 | 0.74 | SLC6A2 (0.48) | MCHR1SLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL6665281 | 0.74 | SLC6A2 (0.48) | MCHR1SLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL9078698 | 0.73 | CYP3A4 (0.42) | TACR2MCHR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6172698 | 0.73 | TACR2 (0.35) | TACR2MCHR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7046390 | 0.70 | TACR2 (0.56) | TACR2TACR1 | |
| SCHEMBL7046387 | 0.70 | TACR2 (0.56) | TACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739891-B1 | Substituted heterocycles | ASTRAZENECA AB (SE) | 2005-01-19 | — | — | EP | disclosed |
| US-6355695-B1 | ANTIHISTAMINES; ASTHMA THERAPY | ZENECA LIMITED (SE) | 2002-03-12 | — | — | US | disclosed |
| US-6235757-B1 | ANTIHISTAMINES | ZENECA LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-6051580-A | Substituted heterocycles | ZENECA LIMITED | 2000-04-18 | — | — | US | disclosed |
| EP-0739891-A2 | Substituted heterocycles | ZENECA LIMITED (GB) | 1996-10-30 | — | — | EP | disclosed |