Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 8/20 | 0.46 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7160505 | 0.84 | NTRK1 (0.39) | NTRK1NTRK2MAPT | |
| SCHEMBL6475543 | 0.83 | KDM4E (0.48) | NTRK1NTRK2HDAC1HDAC8NPC1 | |
| SCHEMBL6486632 | 0.80 | F2 (0.50) | NTRK1NTRK2ACSL1HDAC1HDAC8 | |
| SCHEMBL7244672 | 0.79 | F2 (0.47) | NTRK1NTRK2HDAC1HDAC8NPC1 | |
| Hydrochloric Acid SCHEMBL7244675 | 0.79 | F2 (0.49) | NTRK1NTRK2ACSL1HDAC1HDAC8 | |
| SCHEMBL6159720 | 0.77 | ITK (0.46) | NTRK1NTRK2HDAC1HDAC8NPC1 | |
| SCHEMBL6157976 | 0.77 | NPC1 (0.59) | NTRK1NTRK2ACSL1HDAC1HDAC8 | |
| SCHEMBL7163037 | 0.76 | MAPT (0.41) | NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL6158462 | 0.76 | NTRK1 (0.52) | NTRK1NTRK2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6159112 | 0.75 | NPC1 (0.41) | NTRK1NTRK2HDAC1HDAC8NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210335-B1 | AMINOCARBONYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES, METHOD FOR PRODUCING SAME AND THE USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-09-14 | — | — | EP | disclosed |
| WO-2003024451-A1 | 2-(2-PHENYLETHYL)-BENZIMIDAZOLE-5-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-03-27 | — | — | WO | disclosed |
| EP-1210335-A1 | AMINOCARBONYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES, METHOD FOR PRODUCING SAME AND THE USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001014342-A1 | AMINOCARBONYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES, METHOD FOR PRODUCING SAME AND THE USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-01 | — | — | WO | disclosed |