Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 20/20 | 0.55 |
| ▸ | HTR2C | P28335 | 16/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5052908 | 0.87 | HTR2A (0.66) | HTR2AHTR2C | |
| SCHEMBL29572917 | 0.87 | HTR2A (0.66) | HTR2AHTR2C | |
| SCHEMBL5577961 | 0.87 | HTR2A (0.52) | HTR2AHTR2CKCNH2 | |
| SCHEMBL29572986 | 0.86 | HTR2A (0.77) | HTR2AHTR2C | |
| SCHEMBL5056044 | 0.86 | HTR2A (0.68) | HTR2AHTR2C | |
| SCHEMBL5057449 | 0.86 | HTR2A (0.77) | HTR2AHTR2C | |
| SCHEMBL5057416 | 0.83 | HTR2A (0.66) | HTR2AHTR2CKCNH2 | |
| SCHEMBL29572851 | 0.83 | HTR2A (0.66) | HTR2AHTR2CKCNH2 | |
| SCHEMBL5061706 | 0.82 | HTR2A (0.68) | HTR2AHTR2CKCNH2 | |
| SCHEMBL30343208 | 0.82 | HTR2A (0.68) | HTR2AHTR2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826322-B | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor for the prevention and treatment of related disorders | ARENA PHARM INC | 2012-04-18 | — | — | CN | disclosed |
| CN-101875961-A | Be used to prevent and treat associated conditions and as the diaryl and the aryl heteroaryl urea derivatives of 5-HT2A serotonin receptor modulator | ARENA PHARM INC | 2010-11-03 | — | — | CN | disclosed |
| CN-101871931-A | Be used to prevent and treat associated conditions and as the diaryl and the aryl heteroaryl urea derivatives of 5-HT2A serotonin receptor modulator | ARENA PHARM INC | 2010-10-27 | — | — | CN | disclosed |
| CN-1826322-A | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT 2A serotonin receptor for the prevention and treatment of related disorders | ARENA PHARM INC (US) | 2006-08-30 | — | — | CN | disclosed |
| EP-1558582-B1 | DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2005-12-21 | — | — | EP | disclosed |