SCHEMBL6162374

SCHEMBL6162374

[CH2]Cc1nc(C(C)C)c(Sc2cc(Cl)cc(Cl)c2)n1C

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HSP90B1 P14625 7/20 0.32
TRAP1 Q12931 3/20 0.32
HSP90AA1 P07900 1/20 0.32
HSP90AB1 P08238 1/20 0.32
DRD2 P14416 2/20 0.32
HTR2A P28223 2/20 0.32
HTR7 P34969 2/20 0.32
HTR6 P50406 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6963215 0.89 HSP90B1 (0.32) HSP90B1TRAP1HSP90AA1HSP90AB1DRD2
SCHEMBL6962129 0.88 HSP90B1 (0.32) HSP90B1TRAP1HSP90AA1HSP90AB1DRD2
SCHEMBL6163272 0.88 HSP90B1 (0.33) HSP90B1TRAP1HSP90AA1HSP90AB1DRD2
SCHEMBL6961212 0.88 HSP90B1 (0.34) HSP90B1TRAP1HSP90AA1HSP90AB1DRD2
SCHEMBL6957982 0.86 HSP90B1 (0.31) HSP90B1TRAP1HSP90AA1HSP90AB1DRD2
SCHEMBL6972065 0.85 HSP90B1 (0.33) HSP90B1TRAP1HSP90AA1HSP90AB1DRD2
SCHEMBL6972545 0.85 POLB (0.32) HSP90B1TRAP1HSP90AA1HSP90AB1DRD2
SCHEMBL6967933 0.85 HSP90B1 (0.33) HSP90B1TRAP1HSP90AA1HSP90AB1DRD2
SCHEMBL6969632 0.85 HSP90B1 (0.37) HSP90B1TRAP1HSP90AA1HSP90AB1DRD2
SCHEMBL6963069 0.85 HSP90B1 (0.34) HSP90B1TRAP1HSP90AA1HSP90AB1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0893442-B1 LYMPH-ABSORBABLE IMIDAZOLE DERIVATIVES SHIONOGI & CO (JP) 2005-01-12 EP disclosed
US-6054591-A LYMPHOTROPIC ANTI-AIDS AGENT SHIONOGI & CO., LTD. (JP) 2000-04-25 US disclosed
EP-0893442-A1 LYMPH-ABSORBABLE IMIDAZOLE DERIVATIVES SHIONOGI & CO., LTD. (JP) 1999-01-27 EP disclosed