Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | IDE | P14735 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2638396 | 0.88 | TAAR1 (0.42) | TAAR1CA1CA2CA4CA9 | |
| SCHEMBL7062325 | 0.87 | TAAR1 (0.42) | TAAR1CA1CA2CA4CA9 | |
| SCHEMBL8714458 | 0.85 | TAAR1 (0.40) | TAAR1CA1CA2CA4CA9 | |
| SCHEMBL4022695 | 0.85 | TAAR1 (0.38) | TAAR1L3MBTL1MITFAPAF1IDE | |
| SCHEMBL12501522 | 0.82 | TAAR1 (0.40) | TAAR1CA1CA2CA4CA9 | |
| SCHEMBL20036401 | 0.81 | TAAR1 (0.45) | TAAR1L3MBTL1MITFAPAF1IDE | |
| SCHEMBL28480031 | 0.81 | TAAR1 (0.42) | TAAR1CA1CA2CA4CA9 | |
| SCHEMBL9801301 | 0.80 | TAAR1 (0.39) | TAAR1CA1CA2CA4CA9 | |
| SCHEMBL10385631 | 0.78 | CA1 (0.39) | TAAR1CA1CA2CA4CA9 | |
| SCHEMBL366506 | 0.78 | CA1 (0.42) | TAAR1CA1CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528925-A1 | QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004004732-A1 | QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |