Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.45 |
| ▸ | RAF1 | P04049 | 11/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164680 | 0.87 | MAPK14 (0.43) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6162928 | 0.84 | MAPK14 (0.51) | MAPK14RAF1 | |
| SCHEMBL6163139 | 0.80 | MAPK14 (0.44) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6256613 | 0.75 | MAPK14 (0.47) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL296076 | 0.75 | MAPK14 (0.53) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6256612 | 0.74 | MAPK14 (0.34) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6163203 | 0.70 | MAPK14 (0.47) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6163971 | 0.70 | MAPK14 (0.51) | MAPK14RAF1 | |
| SCHEMBL6164808 | 0.67 | MAPK14 (0.58) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL6162643 | 0.67 | MAPK14 (0.64) | MAPK14RAF1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163236-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6476023-B1 | Aromatic heterocyclic compounds as anti-inflammatory agents | BOEHRINGEN INGELHEIM PHARMACEUTICALS, INC. | 2002-11-05 | — | — | US | disclosed |
| EP-1163236-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2001-12-19 | — | — | EP | disclosed |
| US-6297381-B1 | INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES SUCH AS INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR, UREAS OR THIOUREAS SUBSTITUTED BY A PYRROLE OR THIOPHENE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-10-02 | — | — | US | disclosed |
| WO-2000055152-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |