Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.57 |
| ▸ | ATR | Q13535 | 12/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.54 |
| ▸ | CDK2 | P24941 | 5/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | PRKDC | P78527 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6162823 | 0.88 | GSK3B (0.72) | GSK3BATRCCNE2CCNE1CDK2 | |
| Hydrochloric Acid SCHEMBL6160753 | 0.87 | GSK3B (0.54) | GSK3BATRCCNE2CCNE1CDK2 | |
| Hydrochloric Acid SCHEMBL6160776 | 0.87 | ATR (0.59) | GSK3BATRCCNE2CCNE1CDK2 | |
| Hydrochloric Acid SCHEMBL6170990 | 0.79 | GSK3B (0.49) | GSK3BATRCCNE2CCNE1CDK2 | |
| Hydrochloric Acid SCHEMBL5879316 | 0.79 | GSK3B (0.56) | GSK3BATRCCNE2CCNE1CDK2 | |
| SCHEMBL3157574 | 0.75 | GSK3B (0.80) | GSK3BATRCCNE2CCNE1CDK2 | |
| SCHEMBL23732730 | 0.74 | ATR (0.72) | ATRPRKDC | |
| SCHEMBL3157638 | 0.74 | GSK3B (0.79) | GSK3BATRCCNE2CCNE1CDK2 | |
| Hydrochloric Acid SCHEMBL5879341 | 0.74 | GSK3B (0.53) | GSK3BATRCCNE2CCNE1CDK2 | |
| Hydrochloric Acid SCHEMBL3161860 | 0.73 | GSK3B (0.78) | GSK3BATRCCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575939-A1 | NOVEL COMPOUNDS HAVING SELECTIVE INHIBITING EFFECT AT GSK3 | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004055006-A1 | NOVEL COMPOUNDS HAVING SELECTIVE INHIBITING EFFECT AT GSK3 | ASTRAZENECA AB (SE) | 2004-07-01 | — | — | WO | disclosed |