Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.58 |
| ▸ | ACE | P12821 | 4/20 | 0.52 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.50 |
| ▸ | ITGAL | P20701 | 3/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3014096 | 0.91 | SCN9A (0.68) | SCN9AACEITGB2ICAM1ITGAL | |
| SCHEMBL11439689 | 0.91 | SCN9A (0.68) | SCN9AACEITGB2ICAM1ITGAL | |
| SCHEMBL5253093 | 0.86 | ACE (0.70) | SCN9AACEITGB2ICAM1ITGAL | |
| SCHEMBL5253098 | 0.86 | ACE (0.70) | SCN9AACEITGB2ICAM1ITGAL | |
| SCHEMBL10174744 | 0.86 | ACE (0.70) | SCN9AACEITGB2ICAM1ITGAL | |
| SCHEMBL23270828 | 0.83 | SCN9A (0.63) | SCN9AACEITGB2ICAM1ITGAL | |
| SCHEMBL8939508 | 0.83 | SCN9A (0.63) | SCN9AACEITGB2ICAM1ITGAL | |
| SCHEMBL31278511 | 0.83 | SCN9A (0.63) | SCN9AACEITGB2ICAM1ITGAL | |
| SCHEMBL30346564 | 0.81 | SCN9A (0.53) | SCN9AACEADAM17CTSLCTSS | |
| SCHEMBL29280817 | 0.81 | SCN9A (0.53) | SCN9AACEADAM17CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |