Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167087 | 0.94 | CYP3A4 (0.73) | CYP3A4 | |
| SCHEMBL5869210 | 0.85 | CYP3A4 (0.88) | CYP3A4 | |
| SCHEMBL6164110 | 0.84 | CYP3A4 (0.60) | CYP3A4 | |
| SCHEMBL6164338 | 0.84 | CYP3A4 (0.60) | CYP3A4 | |
| SCHEMBL7140734 | 0.83 | CYP3A4 (0.79) | CYP3A4 | |
| SCHEMBL6167981 | 0.82 | CYP3A4 (0.47) | CYP3A4 | |
| SCHEMBL5869121 | 0.81 | CYP3A4 (1.00) | CYP3A4 | |
| SCHEMBL6167554 | 0.80 | — | — | |
| SCHEMBL6162516 | 0.79 | CYP3A4 (0.57) | CYP3A4 | |
| SCHEMBL7146606 | 0.79 | CYP3A4 (0.70) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-B1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | HOFFMANN LA ROCHE (CH) | 2005-07-20 | — | — | EP | disclosed |
| US-6544985-B2 | For therapy of acute and/or chronic neurological disorders such as psychosis, schizophrenia, Alzheimer's disease, cognitive disorders and memory deficits | HOFFMAN-LA ROCHE INC. | 2003-04-08 | — | — | US | disclosed |