Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.58 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.58 |
| ▸ | TNF | P01375 | 5/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | MUSK | O15146 | 1/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.51 |
| ▸ | PRKCB | P05771 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162643 | 0.85 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL6163916 | 0.84 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL6161897 | 0.79 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL6163999 | 0.77 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL296637 | 0.76 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL6166468 | 0.76 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL29593412 | 0.76 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL6162842 | 0.76 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL6164974 | 0.76 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11TNF | |
| SCHEMBL6161508 | 0.75 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163236-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6476023-B1 | Aromatic heterocyclic compounds as anti-inflammatory agents | BOEHRINGEN INGELHEIM PHARMACEUTICALS, INC. | 2002-11-05 | — | — | US | disclosed |
| EP-1163236-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2001-12-19 | — | — | EP | disclosed |
| US-6297381-B1 | INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES SUCH AS INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR, UREAS OR THIOUREAS SUBSTITUTED BY A PYRROLE OR THIOPHENE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-10-02 | — | — | US | disclosed |
| WO-2000055152-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |