Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.62 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.62 |
| ▸ | DPP4 | P27487 | 4/20 | 0.61 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.61 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.61 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.61 |
| ▸ | FAP | Q12884 | 2/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TACR1 | P25103 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164069 | 0.85 | DPP4 (0.67) | F2PRSS1DPP4DPP8DPP9 | |
| SCHEMBL6053011 | 0.83 | DPP4 (0.65) | F2PRSS1DPP4DPP8DPP9 | |
| SCHEMBL27519212 | 0.83 | DPP4 (0.65) | F2PRSS1DPP4DPP8DPP9 | |
| SCHEMBL31164827 | 0.82 | ACE (0.65) | F2PRSS1DPP4DPP8DPP9 | |
| SCHEMBL2879744 | 0.82 | ACE (0.65) | F2PRSS1DPP4DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL7843586 | 0.82 | DPP4 (0.64) | F2PRSS1DPP4DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL9051934 | 0.82 | DPP4 (0.64) | F2PRSS1DPP4DPP8DPP9 | |
| SCHEMBL28785114 | 0.82 | ACE (0.65) | F2PRSS1DPP4DPP8DPP9 | |
| SCHEMBL2879742 | 0.82 | ACE (0.65) | F2PRSS1DPP4DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL7843587 | 0.82 | DPP4 (0.64) | F2PRSS1DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-0832065-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |