Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 8/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6165882 | 1.00 | HDAC1 (0.53) | HDAC1HDAC3HDAC6ABCG2HDAC4 | |
| SCHEMBL6161811 | 0.86 | HDAC3 (0.62) | HDAC1HDAC3HDAC6ABCG2HDAC4 | |
| SCHEMBL6163655 | 0.86 | HDAC3 (0.62) | HDAC1HDAC3HDAC6ABCG2HDAC4 | |
| SCHEMBL6162959 | 0.85 | HDAC3 (0.57) | HDAC1HDAC3HDAC6ABCG2HDAC4 | |
| SCHEMBL6165639 | 0.85 | HDAC3 (0.57) | HDAC1HDAC3HDAC6ABCG2HDAC4 | |
| SCHEMBL6166053 | 0.84 | HDAC1 (0.69) | HDAC1HDAC3HDAC6KDRMAPT | |
| SCHEMBL6165884 | 0.84 | HDAC1 (0.69) | HDAC1HDAC3HDAC6KDRMAPT | |
| SCHEMBL6165549 | 0.84 | HDAC3 (0.57) | HDAC1HDAC3HDAC6ABCG2HDAC4 | |
| SCHEMBL6162849 | 0.84 | HDAC3 (0.57) | HDAC1HDAC3HDAC6ABCG2HDAC4 | |
| SCHEMBL6160828 | 0.83 | HDAC3 (0.57) | HDAC1HDAC3HDAC6ABCG2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372692-A4 | ASYMMETRIC SYNTHESIS OF (S, S, R)-(-)-ACTINONIN AND ITS ANALOGS AND USES THEREFOR | SLOAN KETTERING INST CANCER (US) | 2005-10-26 | — | — | EP | claimed |
| EP-1218357-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-04-06 | — | — | EP | claimed |
| EP-1372692-A2 | ASYMMETRIC SYNTHESIS OF (S, S, R)-(-)-ACTINONIN AND ITS ANALOGS AND USES THEREFOR | Sloan Kettering Institute For Cancer Research (US) | 2004-01-02 | — | — | EP | claimed |
| WO-2002074050-A2 | ASYMMETRIC SYNTHESIS OF (S, S, R)-(-)-ACTINONIN AND ITS ANALOGS AND USES THEREFOR | SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2002-09-26 | — | — | WO | claimed |