Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 14/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699464 | 0.92 | GRM5 (1.00) | GRM5 | |
| SCHEMBL4297614 | 0.91 | GRM5 (1.00) | GRM5 | |
| SCHEMBL4704750 | 0.81 | GRM5 (0.80) | GRM5 | |
| SCHEMBL14424224 | 0.80 | GRM5 (0.79) | GRM5 | |
| SCHEMBL4698390 | 0.80 | GRM5 (0.77) | GRM5 | |
| SCHEMBL4701515 | 0.80 | GRM5 (0.77) | GRM5 | |
| SCHEMBL4699016 | 0.80 | GRM5 (0.75) | GRM5 | |
| SCHEMBL4699411 | 0.80 | GRM5 (0.77) | GRM5 | |
| SCHEMBL4701728 | 0.79 | GRM5 (0.83) | GRM5 | |
| SCHEMBL4158354 | 0.79 | GRM5 (1.00) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434773-A4 | HETEROARYL SUBSTITUTED TETRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2005-01-12 | — | — | EP | claimed |
| EP-1434773-A2 | HETEROARYL SUBSTITUTED TETRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Merck & Co., Inc. (US) | 2004-07-07 | — | — | EP | claimed |
| WO-2003029210-A2 | HETEROARYL SUBSTITUTED TETRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO. INC. (US) | 2003-04-10 | — | — | WO | claimed |