Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.65 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1365222 | 0.89 | ESR2 (0.62) | ESR2NR1H2HDAC6HDAC8PRMT5 | |
| SCHEMBL31553363 | 0.88 | ESR2 (0.67) | ESR2NR1H2HDAC6HDAC8KDM4E | |
| SCHEMBL31553409 | 0.88 | ESR2 (0.67) | ESR2NR1H2HDAC6HDAC8KDM4E | |
| SCHEMBL14063092 | 0.87 | ESR2 (0.69) | ESR2NR1H2HDAC6HDAC8NAMPT | |
| SCHEMBL30301758 | 0.84 | ESR2 (0.69) | ESR2NR1H2HDAC6HDAC8KDM4E | |
| SCHEMBL3024823 | 0.84 | ESR2 (0.69) | ESR2NR1H2HDAC6HDAC8KDM4E | |
| SCHEMBL5077823 | 0.84 | NR1H2 (0.61) | ESR2NR1H2HDAC6HDAC8PRMT5 | |
| SCHEMBL29406723 | 0.84 | ESR2 (0.72) | ESR2NR1H2HDAC6HDAC8KDM4E | |
| SCHEMBL1365145 | 0.84 | ESR2 (0.72) | ESR2NR1H2HDAC6HDAC8GPR119 | |
| SCHEMBL306991 | 0.84 | ESR2 (0.72) | ESR2NR1H2HDAC6HDAC8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |
| WO-1996035713-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER, INC. (US) | 1996-11-14 | — | — | WO | disclosed |