SCHEMBL6165886

SCHEMBL6165886

NC(=O)NN=Cc1ccc(Oc2ccc([N+](=O)[O-])cc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN4A P35499 1/20 0.67
SCN9A Q15858 1/20 0.67
MAPT P10636 10/20 0.64
MAOB P27338 1/20 0.64
CTDSP1 Q9GZU7 1/20 0.59
HTT P42858 1/20 0.57
IKBKB O14920 1/20 0.53
RAB9A P51151 4/20 0.52
NPC1 O15118 3/20 0.52
POLB P06746 2/20 0.52
GAA P10253 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
ALDH1A1 P00352 3/20 0.51
CYP3A4 P08684 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2D6 P10635 1/20 0.51
HIF1A Q16665 1/20 0.51
KDM4E B2RXH2 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8433110 0.92 MAPT (0.75) MAPTMAOBCTDSP1HTTIKBKB
SCHEMBL25243618 0.92 MAPT (0.75) MAPTMAOBCTDSP1HTTIKBKB
SCHEMBL6165996 0.81 SCN4A (0.76) SCN4ASCN9AMAPTCTDSP1HTT
SCHEMBL1105594 0.81 SCN4A (0.76) SCN4ASCN9AMAPTCTDSP1HTT
SCHEMBL6164077 0.80 SCN4A (1.00) SCN4ASCN9AMAPTHTTRAB9A
SCHEMBL6165837 0.80 SCN4A (0.74) SCN4ASCN9AMAPTHTTRAB9A
SCHEMBL6166125 0.80 SCN4A (0.74) SCN4ASCN9AMAPTHTTRAB9A
SCHEMBL6162208 0.80 SCN4A (0.74) SCN4ASCN9AMAPTRAB9ANPC1
SCHEMBL6163679 0.80 SCN4A (0.74) SCN4ASCN9AMAPTCTDSP1HTT
SCHEMBL29405312 0.80 SCN4A (1.00) SCN4ASCN9AMAPTHTTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0986540-B1 THE USE OF CARBOCYCLIC AND HETEROCYCLIC SUBSTITUTED SEMICARBAZONES AND THIOSEMICARBAZONES AS SODIUM CHANNEL BLOCKERS EURO CELTIQUE SA (LU) 2005-02-16 EP claimed