Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4714837 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL3781362 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL30706089 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL18921640 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL30289121 | 0.77 | SMN1; SMN2 (0.51) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL26705305 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL30602886 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL30179036 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL16896060 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP2C19NPC1RAB9AHTT | |
| SCHEMBL9144556 | 0.75 | HTT (0.51) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134219-B1 | CYCLOALKYL-SUBSTITUTED AMINOMETHYLPYRROLIDINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2005-06-15 | — | — | EP | disclosed |
| EP-1134219-A1 | CYCLOALKYL-SUBSTITUTED AMINOMETHYLPYRROLIDINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-09-19 | — | — | EP | disclosed |